Evaluation of microalbumin, cystatin c, creatinine and uric acid levels in HIV patients in Nnamdi Azikiwe University Teaching Hospital, Nnewi


Original Article

Author Details : Ezeugwunne Ifeoma Priscilla*, Amaifeobu Clement, Meludu Samuel Chukwuemeka, Analike Rosemary Adamma, Nnamdi Johnjude Chinonso, Oguaka Victor Nwabunwanne, Izuchukwu Emeka Callistus Onyeka, Nduka Nonso Samuel, Aikpitanyi Iduitua GA

Volume : 8, Issue : 3, Year : 2021

Article Page : 132-142

https://doi.org/10.18231/j.jchm.2021.030



Suggest article by email


Abstract

This study evaluated the microalbumin, cystatin C, creatinine and uric acid levels in HIV patients in Nnamdi Azikiwe University Teaching Hospital, Nnewi (NAUTH). A total of one hundred (100) male and female HIV positive and control participants who were aged between 18 and 60 years attending the voluntary counseling and testing unit (VCT) and antiretroviral therapy unit (ART) of NAUTH were randomly recruited for the study and grouped thus: Group A (HIV positive symptomatic participants on long term ART (HPSPLTART) (n= 25); Group B (HIV positive symptomatic participants on short term ART (HPSPSTART) (n= 25); Group C: Asymptomatic HIV positive participants NOT on ART (AHPPNART) (n=25) and Group D: control (n=25).6mls of blood sample and 10mls of freshly voided urine samples were collected from each of the participants for the evaluation of biochemical parameters using standard laboratory methods. Results showed significantly higher BMI and SBP in HPSPSTART than in control (p=0.04; 0.02). SBP was significantly higher in HPSPLTART than in AHPPNART and Control (p=0.00). DBP was significantly higher in HPSPLTART than in HPSPSTART and control respectively (p=0.00). There were significantly higher plasma creatinine and Cys-C levels in both male HIV positives and male HIV positive participants on ART than in both females respectively (p0.00; 0.02). Also, BMI, creatinine, uric acid and Cystatin C levels were significantly higher in male HIV negative participants than in female HIV negative participants (p=0.00; 0.04; 0.02; 0.01). This study has revealed greater risk for renal disease among the HIV participants studied.


Keywords: HIV, Kidney, Kidney function, Microalbumin, cystatin-C, creatinine, Uric acid, Males, Females


How to cite : Priscilla E I, Clement A, Chukwuemeka M S, Adamma A R, Chinonso N J, Nwabunwanne O V, Onyeka I E C, Samuel N N, Aikpitanyi Iduitua Ga, Evaluation of microalbumin, cystatin c, creatinine and uric acid levels in HIV patients in Nnamdi Azikiwe University Teaching Hospital, Nnewi. J Community Health Manag 2021;8(3):132-142


Copyright © 2021 by author(s) and J Community Health Manag. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (creativecommons.org)





Article History

Received : 06-09-2021

Accepted : 13-09-2021

Available online : 22-10-2021


View Article

PDF File   Full Text Article


Copyright permission

Get article permission for commercial use

Downlaod

PDF File   XML File   ePub File


Digital Object Identifier (DOI)

Article DOI

https://doi.org/10.18231/j.jchm.2021.030


Article Metrics






Article Access statistics

Viewed: 106

PDF Downloaded: 33



Wiki in hindi